Documentation of pharmacogenomic markers allele frequencies
- 24 February 2011
- Super User
FINDbase database also documents the frequencies of causative mutations leading to inherited disorders in various populations worldwide [Georgitsi et al., 2011]. Database records include the population, the ethnic group and/or the geographic region, the gene name and its variation parameters, the rare allele frequencies, accompanied by links to the respective Online Mendelian Inheritance in Man (OMIM) and the Pharmacogenomics knowledgebase (PharmGKB) entries. All entries are recorded against their unique PubMed and ResearcherIDs. The current data collection of this module includes curated allelic frequency data for 144 pharmacogenomic markers for 14 genes of pharmacogenomic interest. Data have been col¬lected via literature data mining of 214 scientific articles, representing approximately 87,000 indi¬viduals from 150 populations worldwide and across all continents. As a result, this module of FINDbase represents a worldwide collection of phar¬macogenomic markers, and fills in a gap left by other pharmacogenomics knowledgebases and related resources.
